© The Nobel Foundation
Joseph L. Goldstein

American Jewish Recipients of the Nobel Prize

Joseph L. Goldstein: Nobel
Prize in Physiology or

by Seymour “Sy” Brody

Joseph L. Goldstein is an American Jewish Recipient of the Nobel Prize in Physiology or Medicine, which he shared with Michael S. Brown for their discoveries concerning the regulation of a cholesterol metabolism.

Joseph L. Goldstein was born on April 18, 1940, in Sumter, South Carolina. He was the only son of Fannie (nee Alpert) and Isadore E. Goldstein. His parents owned a clothing store, in Kingstree, South Carolina.

He attended Washington and Lee University, in Lexington, South Carolina. He graduated with a B.S. Degree in Chemistry, summa cum laude, in 1962. Goldstein entered Southwestern Medical School, of the University of Texas Health Science Center, in Dallas, Texas.

Goldstein was motivated by Donald W. Seldin, Chairman of the Department of Internal Medicine, to pursue a career in academic medicine. He received his M.D. Degree, in 1966. He became an Intern and Resident in Medicine at Massachusetts General Hospital in Boston (1966-1968). It was here that he met and developed a longtime friendship with Michael S. Brown. They were collaborators on their research and speaking engagements.

After he completed his medical training, he spent two years, 1958-1970, at the National Institutes of Health working in the laboratory of Marshall Nirenberg. He also served as a clinical associate at the National Heart Institute.

In 1971, he became an Assistant Professor, in Seldin’s Department of Internal Medicine, at Texas University, 1972. He also undertook to be the head of the medical school’s first Division of Medical Genetics. In 1974, he was elevated to Associate Professor, and in 1977, he was made a Professor.

Joseph L. Goldstein had many memberships, honors and awards:
• National Academy of Sciences, 1980
• American Association of American Physicians
• American Society Clinical Investigation (President, 1985-1986)
• American Society of Biological Chemists
• American Society of Human Genetics
• American Society of Cell Biology
• American Federation for Clinical Research
• A Fellow of the American College of Physicians
• A Diplomate of the Internal Board of Internal Medicine
• Served on study sections of the American heart Association, 1975-1978
• Served for the National Institutes of Health. 1975-1978
• Honorary Doctor of Science, University of Chicago, 1982
• Honorary Doctor of Science, Rensselaer Polytechnic Institute, 1982
• Heinrich Wieland Prize for Research in Lipid Metabolism, 1974 (shared with Michael Brown)
• Pfizer Award for Enzyme Chemistry of the American Chemical Society, 1976 (shared with Michael Brown)
• Albion O. Bernstein Award of the New York State Medical Society, 1977 (shared with Michael Brown)
• Passano Award, 1978 (shared with Michael Brown)
• Lounsbery Award of the U.S. Academy of Science, 1979 (shared with Michael Brown)
• Gairdner Foundation International, 1981 (shared with Michael Brown)
• New York Academy of Sciences Award in Biological and Medical Sciences, 1979 (shared with Michael Brown)
• Lita Annenberg Hazen Award, 1982 (shared with Michael Brown)
• V.D. Mattia Award of the Roche Institute of Molecular Biology, 1984 (shared with Michael Brown )
• Distinguished Research Award of the Association of American Medical Colleges, 1984 (shared with Michael Brown)
• Research Achievement Award of the American Heart Association, 1984 (Shared with Michael Brown)• Louise Gross Horwitz Award, 1984 (shared with Michael Brown)
• 3M Life Sciences Award of the Federation of American Societies for Experimental Biology, 1985 (shared with Michael Brown)
• William Allan Award of the American Society of Human Genetics, 1985 (shared with Michael Brown)
• Albert D. Lasker Award in Basic Medical Research, 1985 (shared with Michael Brown).

Joseph Goldstein and Michael Brown have jointly given many lectures on their work to many universities and scientific organizations.

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